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KMID : 0388419990090010173
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Konkuk Journal of Medical Sciences
1999 Volume.9 No. 1 p.173 ~ p.180
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Comparison of the Effects of Propofol, Ketamine and Enflurane on PaO2 and PaCO2 during One Lung Ventilation
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Kim Yoon-Soo
Kim Min-Jung
Lee Kyu-Chang
Woo Nam-Sik
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Abstract
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The mechanism which normally affects distribution of blood flow through unventilated areas of the lung is hypoxic pulmonary vasoconstriction, this acts to divert the blood to well ventilated alveoli, resulting in a better ratio of ventilation to perfusion. Several reports have focused attention to the reduction or abolition of this reflex in the unventilated lung by most volatile anesthetic agents used in clinical practice. This response was not abolished by the intravenous anesthetic agents.
30 patients undergoing elective thoracic surgery were studied to evaluate the effect of a propofol(n=10), ketamine(n=10) and enflurane(n=10) on the changes in PaO2 and in PaCO2 as reflections of shunt and ventilation
respectively during one lung anesthesia. We have demonstrated that in all cases a PaO2 in excess of 105.3㎜Hg, 79.5㎜Hg, and 177㎜Hg were achived with propofol, ketamine and enflurane. In all cases a PaCO2 was under the 36.8㎜Hg. We concluded that both propofol and enflurane were satisfactory anesthetics for one-lung anesthesia. and ketanine was not ideal for one-lung anesthesia in adult patients.
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KEYWORD
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one lung anesthesia, propofol, ketamine, enflurane,
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